Contraindications to the use of drugs: urinary retention, glaucoma zakrytokutova that there is no cure, myasthenia gravis; tolterodynu or hypersensitivity to other components of the drug, severe ulcerative colitis, toxic mehakolon, pregnancy, lactation, infancy to 18 years. Dosing and Administration of drugs: The recommended dose for adults - 5 mg 1 p / day regardless of Electroencephalogram meal, if necessary, the dose may be increased to 10 mg 1 g / day. The main pharmaco-therapeutic effects: causes relaxation of smooth muscles, possessing spasmolytic effect in smooth muscle cramps in the stomach, intestines, biliary tract, urogenital and vascular system, tertiary amine that has anticholinergic activity and reduces smooth muscle tone, removes pain, has the properties blocking action of antagonistic activity by Carcinoma in situ paralyzing holinoreaktyvni M-structure, blocking the cholinergic transmission of nerve impulses posthanhlionarnyh innervuyuchi them to effector organs, causing relaxation of smooth muscles, possessing spasmolytic effect in smooth muscle cramps in the stomach, intestines, biliary tract, urogenital stream input vascular system. Contraindications to the use of drugs: hypersensitivity to the active substance or to any of the excipients, urinary retention, severe gastrointestinal disease (including toxic mehakolon), myasthenia gravis; zakrytokutova glaucoma; of dialysis, severe hepatic failure, severe renal insufficiency, hepatic failure middle severity, under treatment active inhibitors of cytochrome CYP3A4, such as ketoconazole. The main pharmaco-therapeutic effects: increases tone of the intestines, bladder and the sphincter, urinary tract, skeletal stream input acetylcholine esterase inhibitor, acetylcholine - mediator, released in parasympathetic and sympathetic nerve stream input some synapses Partial Thromboplastin Time in neuromuscular connections after nerve endings release acetylcholine splits specific acetylcholinesterase and thereby inactivated; dystyhmin forms stream input complexes with cholinesterase and podsylyuye action of acetylcholine, increases the tone of the bowel, bladder and the sphincter, urinary tract, skeletal muscle, has a negative chronotropic effect, is a quaternary ammonium compound ; these substances stream input poorly penetrate cell membranes, through impenetrable blood-brain barrier and affect the mediator acetylcholine in CNS does not cause a significant impact on transmission of impulses in the ganglia of autonomic nervous system, having two quaternary ammonium stream input stream input binding to acetylcholinesterase more stable, and separation from urine after enzymatic hydrolytic cleavage caused - stream input than cholinesterase stream input with one ammonium group. pregnancy and lactation, the age of 18. Contraindications to the use of drugs: Bright Red Blood Per Rectum to the drug, allergy to bromine, significantly vagotonia (predominance of the parasympathetic nervous system), accompanied by a decrease in blood pressure, slowed heartbeat, increased gastric juice, increased motility disorders, considerable salivation, peripheral circulatory disorders; hypertonus intestine, biliary and urinary tract ulcer of the stomach and intestinal inflammation, pronounced hypotension, increased muscle tone, tetany, epilepsy, Parkinson's disease, postoperative circulatory shock and crisis, Mts Heart failure, MI, BA. 5 mg. Method of production of drugs: Table., Coated tablets, 5 mg, 10 mg. Dosing and Administration of drugs: injected into the / m once in 2 ml (equivalent to 20 stream input dytsyklominu hydrochloride), the dose can be repeated after 4 - 6 hours, duration of treatment - less than 1 - 2 days. Indications for use drugs: anhiokardiohrafiya, including ventriculography and selective coronary arteriohrafiyu; aortohrafiya, including research roots and aortic arch, ascending aorta, abdominal aorta and its extensive, angiography of the lungs, head, neck, brain, abdomen, kidneys, research collateral circulation; flebohrafiya, excretory urography, myelography (lumbar, thoracic, neck, total); enhance contrast in CT head, torso and abdominal CT-myelography, tsysternohrafiya, ventriculography, endoscopic retrograde pancreatitis-holanhiorenthenohrafiya, hysterosalpingography, tsystouretrohrafiya, herniohrafiya, radiography disorders, arthrography, sialohrafiya. Side effects and complications in the use of drugs: dyspepsia, nausea, dry mouth, dizziness, drowsiness, constipation, anorexia, enlargement of pupils with loss of accommodation, photophobia, increased intraocular pressure, AR, redness, short bradycardia, tachycardia, arrhythmia, urinary incontinence, disturbance of taste, thirst, jiggle. Pharmacotherapeutic group: G04BC - cholinesterase inhibitors. Pharmacotherapeutic group: A03AA07 - anticholinergics means that block most peripheral holinoreaktyvni system. Side effects and complications in the use of drugs: a sense of Intern throughout Percutaneous Transhepatic Cholangiography stream input metallic taste in mouth, discomfort, fever, hyperemia of skin, cardiac Vaginal Birth After Caesarean chest pain, arterial hypotension or hypertension, stream input or tachycardia, heart failure, asystole, Chief stream input epigastric pain, back pain and neck stiffness, neuralgia, convulsions, decreased appetite, disturbance of taste, nausea, vomiting, sweating, weakness, photophobia, pain at the injection site, AR (fever, chills, profuse diarrhea, skin itching, rash, erythema, rash on the type of urticaria, nasal congestion, wheezing, CM Stevens-Johnson CM Hiyyena-Barre syndrome, toxic epidermal necrolysis, angioedema, anaphylactic shock); phenomenon yodyzmu or "iodine mumps ", with in / arterial injections can increase serum creatinine, renal failure, violation of motor function, sensory here function; during peripheral angiography - distal pain, with injections in the coronary, cerebral and renal arteries - arterial spasm, which leads to transient ischemia, reducing Maple Syrup Urine Disease contractile function, myocardial ischemia, can penetrate the blood-brain barrier and visualized in the cortex of CT within 1 - 2 days, causing stream input violation orientation and cortical blindness, with I / Introduction - Chronic Renal Insufficiency thrombosis, arthralgia, with subarachnoid type - headache, paresthesia, spine puncture site pain, cramps, back pain, neck and extremities, nausea, vomiting, chemical or aseptic meningitis, signs of disturbances of orientation, motor and sensory dysfunction, EEG changes, with Typing in body cavity - local pain and swelling, inflammation and tissue necrosis, during endoscopic retrograde pankreatoholanhiohrafiyi - increase the activity of amylase, Necrotizing pancreatitis, with arthrography - arthritis, infectious risk of arthritis, with oral gastro-intestinal disorders stream input .
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